Practical Synthesis of 5-Aminolevulinic Acid ffom N-Acetylfurfurylamine.
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چکیده
منابع مشابه
5-Aminolevulinic acid synthesis in Escherichia coli.
A hemA mutant of Escherichia coli containing a multicopy plasmid which complemented the mutation excreted 5-aminolevulinic acid (ALA) into the medium. [1-14C]glutamate was substantially incorporated into ALA by this strain, whereas [2-14C]glycine was not. Periodate degradation of labeled ALA showed that C-5 of ALA was derived from C-1 of glutamate. The synthesis of ALA by two sonicate fractions...
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BACKGROUND AND AIMS Trypanosoma cruzi is the causative agent of Chagas disease or American trypanosomiasis. The parasite manifests a nutritional requirement for heme compounds because of its biosynthesis deficiency. The aim of this study has been to investigate the presence of metabolites and enzymes of porphyrin pathway, as well as ALA formation in epimastigotes of T. cruzi, Tulahuén strain, T...
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The molecule 5-aminolevulinic acid (5-ALA) is a substrate for a heme synthesized in cells us‐ ing succinyl CoA and glycine. Initially, 5-ALA is converted to porphobilinogen (PBG), and the metabolism progresses by the action of PBG deaminase, and its product is incorporated into the mitochondria via uroporphyrinogen and coproporphyrinogen by an enzymatic reaction and transformed into protoporphy...
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The details of this condensation and the mechanisms involved were not elucidated until very recently. In the last few months, several laboratories have independently reported their preliminary findings demonstrating the enzymatic synthesis of 6aminolevulinic acid. We have found that particle-free extracts of Rhodopseudomonas spheroides and Rhodosp&%llum rubrum cells grown anaerobically in the l...
متن کاملPractical Considerations in the Pharmaceutical Analysis of Methyl and Hexyl Ester Derivatives of 5-Aminolevulinic Acid
Photodynamic therapy (PDT) using topical 5-aminolevulinic acid (ALA), a water-soluble precursor of the potent endogenous photosensitiser, protoporphyrin IX (PpIX), is a treatment and diagnostic tool for premalignant and malignant skin cancers. However, to improve drug delivery to deeper skin lesions, more lipophilic ALA esters have been investigated. Owing to the necessity in drug delivery rese...
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ژورنال
عنوان ژورنال: NIPPON KAGAKU KAISHI
سال: 1999
ISSN: 2185-0925,0369-4577
DOI: 10.1246/nikkashi.1999.199